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| [Studien
- ] Publiziert 2001-02-04 00:00:00 Whatley-Studie Abstrakt ( Kurzfassung ) 1: Neuroreport 1998 May 11;9(7):1391-5 Related Articles, Books, LinkOut Phosmet induces up-regulation of surface levels of the cellular prion
protein. Gordon I, Abdulla EM, Campbell IC, Whatley SA Department of Neuroscience, Institute of Psychiatry, London, UK. Chronic (2 day) exposure of human neuroblastoma cells to the
organophosphate pesticide phosmet induced a marked
concentration-dependent increase in the levels of PrP present on the
cell surface as assessed by biotin labelling and immunoprecipitation.
Levels of both phospholipase C (PIPLC)-releasable and non-releasable
forms of PrP were increased on the plasma membrane. These increases
appear to be due to post-transcriptional mechanisms, since PrP mRNA
levels as assessed by Northern Blotting were unaffected by phosmet
treatment. These data raise the possibility that phosmet exposure may
increase the risk to prion diseases by altering the levels of PrP
accessible to external prions. |
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